Study Identifies Safe Delivery System for Tricky Yet Potent Anti-Cancer Cancer Compound

Researchers at the University of California, San Diego School of Medicine have discovered a way to effectively deliver staurosporine (STS), a powerful anti-cancer compound that has vexed researchers for more than 30 years due to its instability in the blood and toxic nature in both healthy and cancerous cells.  For the first time, the new method safely delivered STS to mouse tumors, suppressing them with no apparent side effects. The results were published online, October 20, in the International Journal of Nanomedicine.

“By itself, staurosporine shows potent activity against a number of cancer cell lines, including chemotherapy-resistant tumors. However, it also harms normal tissue,” said senior author Santosh Kesari, MD, PhD, director of neuro-oncology at UC San Diego Moores Cancer Center. “With this study, we have been able to overcome the pharmacokinetic barriers to delivering staurosporine to tumors with the use of liposomes.”

STS was originally isolated from the bacterium Streptomyces staurosporeus in 1977. The compound prompts a wide variety of cancer cell types to self-destruct, a process called apoptosis or programmed cell death.  In its free form, STS is quickly metabolized and harmful to healthy cells. By trapping STS in tiny spheres called liposomes, Moores Cancer Center researchers have been able to effectively deliver the compound, past healthy tissue, to the tumor, with potent results.

Liposomes are microscopic bubbles made from the same molecules as cell membranes. Researchers use these hollow spheres to deliver therapeutic agents. Anti-cancer drugs can be loaded inside, while disguising agents coat the external membrane surface to hide the cancer-killer from the immune system.

“Staurosporine is able to drive virtually any mammal cell into apoptosis. It is able to uniquely interfere with several cell signaling pathways, even in cancer cell lines that defy frontline chemotherapy agents,” said Milan Makale, PhD, a project scientist at UC San Diego Moores Cancer Center. “In the case of treatment-resistant brain, colon or pancreatic cancers, the potency of staurosporine stacks the odds in our favor of improving current treatments and outcomes. With an appropriately engineered liposomal delivery system, we can finally keep the drug in the blood longer, get it into the tumor better, and to a significant degree, spare healthy tissue.”

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