UC San Diego Research Funded By CIRM to Identify Potential Autism Drug Targets
A researcher at the University of California, San Diego School of Medicine is among principal investigators at 10 California institutions receiving Early Translational IV Research grants, totaling $40 million, approved today by the governing board of the California Institute for Regenerative Medicine (CIRM) at its meeting in San Diego.
Alysson R. Muotri, PhD, assistant professor of pediatrics and cellular and molecular medicine, will receive approximately $1.85 million for his research using induced pluripotent stem (iPS) cells, with the aim of identifying novel small molecule drugs with the potential to treat autism spectrum disorder.
“This project is based on the hypothesis that astrocytes, one of the main support cells in the central nervous system, play an important role in the formation and function of neural connections,” said Muotri.
Astrocytes will be obtained by in-vitro differentiation of iPS cells derived from patients with autism spectrum disorder. Muotri and colleagues did something similar in 2010 when they used iPSCs from patients with Rett syndrome to create the first functional human cellular model for studying the development of autism spectrum disorders.
“This work is important because it puts us in a translational mode,” Muotri said. “It helps expand and deepen our understanding of autism, from a behavioral disorder to a developmental brain disorder. We can now look for and test drugs and therapies and see what happens at a cellular and molecular level.”
More here

UC San Diego Research Funded By CIRM to Identify Potential Autism Drug Targets

A researcher at the University of California, San Diego School of Medicine is among principal investigators at 10 California institutions receiving Early Translational IV Research grants, totaling $40 million, approved today by the governing board of the California Institute for Regenerative Medicine (CIRM) at its meeting in San Diego.

Alysson R. Muotri, PhD, assistant professor of pediatrics and cellular and molecular medicine, will receive approximately $1.85 million for his research using induced pluripotent stem (iPS) cells, with the aim of identifying novel small molecule drugs with the potential to treat autism spectrum disorder.

“This project is based on the hypothesis that astrocytes, one of the main support cells in the central nervous system, play an important role in the formation and function of neural connections,” said Muotri.

Astrocytes will be obtained by in-vitro differentiation of iPS cells derived from patients with autism spectrum disorder. Muotri and colleagues did something similar in 2010 when they used iPSCs from patients with Rett syndrome to create the first functional human cellular model for studying the development of autism spectrum disorders.

“This work is important because it puts us in a translational mode,” Muotri said. “It helps expand and deepen our understanding of autism, from a behavioral disorder to a developmental brain disorder. We can now look for and test drugs and therapies and see what happens at a cellular and molecular level.”

More here

Notes

  1. mslexip reblogged this from ucsdhealthsciences
  2. aforam reblogged this from ucsdhealthsciences
  3. ghostofdragon reblogged this from ucsdhealthsciences
  4. medregenliou reblogged this from ucsdhealthsciences
  5. iobliterate reblogged this from ucsdhealthsciences
  6. arrangedderangements reblogged this from ucsdhealthsciences
  7. conflictavoidsme reblogged this from ucsdhealthsciences
  8. kldismuk reblogged this from ucsdhealthsciences
  9. kelisewright reblogged this from ucsdhealthsciences
  10. healthnt reblogged this from ucsdhealthsciences
  11. millennial3000 reblogged this from ucsdhealthsciences
  12. ellistarr87 reblogged this from ucsdhealthsciences
  13. happyhornyhigh reblogged this from ucsdhealthsciences
  14. texasdreamer01 reblogged this from ucsdhealthsciences

About

News from UC San Diego Health Sciences
Media Contacts: 619-543-6163
HealthSciComm@ucsd.edu

Blogroll

  • instagram
  • sdzsafaripark
  • ari-abroad
  • kenobi-wan-obi
  • azspot
  • lakeconews
  • guardian
  • laboratoryequipment
  • theweekmagazine
  • neurosciencestuff
  • kqedscience
  • forum-network
  • pubhealth
  • wayfaringmd
  • journalofajournalist
  • dodgemedlin
  • pulitzercenter
  • nypl
  • awomaninscience
  • sciencenetlinks
  • scientificillustration
  • nprfreshair
  • longform
  • medicalschool
  • scinerds
  • huffingtonpost
  • colchrishadfield
  • newswatchtv
  • whitehouse
  • pacificstand
  • amnhnyc
  • statedept
  • newsweek
  • currentsinbiology
  • nursefocker
  • mothernaturenetwork
  • themedicalchronicles
  • boston
  • oupacademic
  • smithsonianmag
  • newyorker
  • breakingnews
  • scienceyoucanlove
  • todaysdocument
  • post-mitotic
  • medindia
  • md-admissions
  • cranquis
  • nursingmonkeymomma
  • fyeahmedlab
  • missmdisme
  • psychotherapy
  • seltzerlizard
  • natgeofound
  • codeit
  • tballardbrown
  • comedycentral
  • queerability
  • alscientist
  • scientificthought
  • ohscience
  • cancerninja
  • wnyc
  • bbglasses
  • latimes
  • healthcareinfoguide
  • fastcompany
  • madsweat
  • futureofscience
  • aspiringdoctors
  • mindblowingscience
  • katiecouric
  • molecularlifesciences
  • denverpost
  • inothernews
  • medresearch
  • publicradiointernational
  • sdzoo
  • dystrophin
  • abcworldnews
  • buzzfeed
  • therumpus
  • exploratorium
  • rollingstone
  • pbstv
  • npr
  • htdeverything
  • thevancouversun
  • nbcnightlynews
  • theonion
  • mathcat345
  • think-progress
  • nbcnews
  • theatlantic
  • jtotheizzoe
  • yahoonews
  • nprinterns
  • theskygazer
  • ucsdspecialcollections
  • pozmagazine
  • robotmuesli
  • prochoiceamerica
  • explore-blog
  • officialssay
  • laweekly
  • onaissues
  • infographicjournal
  • prnewswire
  • usagov
  • ucsdmedialab
  • thisissandiego
  • usnews
  • wired
  • tmagazine
  • doctorswithoutborders
  • mashablehq
  • nydailynews
  • thenewrepublic
  • nprglobalhealth
  • columbusdispatch
  • kateoplis
  • surfnrunnr
  • peacecorps
  • plannedparenthood
  • sesamestreet
  • cenwatchglass
  • austinstatesman
  • yaleuniversity
  • medicalstate
  • soupsoup
  • actgnetwork
  • shortformblog
  • today
  • breakingblog
  • sciencesoup
  • psydoctor8
  • thescienceofreality
  • huffpostscience
  • cnbc
  • highcountrynews
  • scienceisbeauty
  • reuters
  • thisisfusion
  • newshour
  • photojojo
  • ucsdcancer
  • artandsciencejournal
  • msnbc
  • 3rdofmay
  • nprradiopictures
  • galindoyadira
  • markcoatney
  • skunkbear
  • thedailyshow
  • libertasacademica
  • mediclopedia
  • robertreich
  • usatoday
  • bbsrc
  • staff
  • ucresearch
  • pritheworld
  • unicef
  • washingtonexaminer
  • michiganengineering
  • neurolove
  • bostongyrig
  • csmonitor
  • motherjones
  • ottawahealth
  • minnpost
  • doublejack
  • ucsdcrossculturalcenter
  • shortyawards
  • wnycradiolab
  • science-and-logic
  • pbsthisdayinhistory
  • hospitalreina
  • sciencechicks
  • americanpublicmedia
  • brookhavenlab
  • discoverynews
  • ziyadnazem
  • scipak
  • nocturnalnurse
  • nysci
  • tedx
  • nurse-on-duty
  • sciencenote
  • jayparkinsonmd
  • ladyjournos
  • poptech
  • ucsdcareerservicescenter
  • mediamed
  • brainmtters
  • aarp
  • neuroanatomyblog
  • nprontheroad
  • articulomortis
  • science
  • poynterinstitute
  • timelightbox
  • artpoweratucsd
  • timemagazine
  • matthewkeys
  • paraphyletic
  • upworthyinsider
  • ucsd
  • topherchris
  • oh4theloveofscience
  • fuckyeahneuroscience
  • pneupnurse
  • utnereader
  • biocanvas
  • joshherigon
  • fuckyeahcardiovascularsystem
  • bitesizedbiology
  • bobedwardsradio
  • medethicslady
  • phdr
  • picturedept
  • fuckyeahnervoussystem
  • sci-fact
  • nationalpost
  • goodideapublichealth
  • carlzimmer
  • vetstail
  • chronicleofhighered
  • wgbhnews
  • ruled-by-secrecy
  • anaofta
  • tumblmd
  • life
  • dailymedical
  • oceanportal
  • ahfspeakout
  • captain-nitrogen
  • lookslikescience
  • genannetics
  • clearscience
  • thecoloradopursuit
  • artneuroscience
  • auditoryinsomniac
  • blamoscience
  • scishow
  • bio-sustain
  • information101
  • sciencephotolibrary
  • rubylipstick1
  • itsjustcharli
  • stemcellculture
  • houseofmind
  • scotthensley
  • a-science-blog
  • cheatsheet
  • bklynmed
  • bartholomewfromthesun
  • salon
  • wellcomebrains
  • aljazeera
  • globeandmail
  • kpcc
  • princeton-medbloro
  • blue-lights-and-tea
  • geneticist
  • couturecourier
  • reportingonhealth
  • ucsfbioengineering
  • coolhealthinfographics
  • thedailywhat
  • villagevoice
  • nbclatino
  • y2ycenter
  • ajebsary
  • realcleverscience
  • ohyeahdevelopmentalbiology
  • guardiancomment
  • timesopinion
  • scientificbritain
  • lifescienceexperiment
  • adschu
  • drwhitehall
  • poptechlabs
  • tokenladyscientist
  • washingtonpostinnovations
  • mountainlake
  • everythingmedical101
  • sdcms
  • mpbntech
  • kusp
  • natgeo