First image (purple) depicts cultured, self-renewing primitive neural precursors derived from human embryonic stem cells using small molecule inhibitors. Second image (red, yellow, green) depicts stained mature neurons, derived from precursor cells, expressing the neurotransmitter, dopamine.

Scientists Create Stable, Self-Renewing Neural Stem Cells

In a paper published in the April 25 early online edition of the Proceedings of the National Academy of Sciences, researchers at the University of California, San Diego School of Medicine, the Gladstone Institutes in San Francisco and colleagues report a game-changing advance in stem cell science: the creation of long-term, self-renewing, primitive neural precursor cells from human embryonic stem cells (hESCs) that can be directed to become many types of neuron without increased risk of tumor formation.

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