Human adipose tissue (fat).
Knocking Out Key Protein in Mice Boosts Insulin Sensitivity
By knocking out a key regulatory protein, scientists at the University of California, San Diego School of Medicine and the Ecole Polytechnique Federale de Lausanne (EPFL) in Switzerland dramatically boosted insulin sensitivity in lab mice, an achievement that opens a new door for drug development and the treatment of diabetes.
The research, published in the November 11 issue of the journal Cell, reveals a new and previously unsuspected role for nuclear receptor corepressor (NCoR), a transcriptional coregulatory protein found in a wide variety of cells.
“Different transcription factors stimulate genes, turning them on and off, by bringing in co-activators or co-repressors,” said Jerrold M. Olefsky, MD, associate dean for Scientific Affairs and Distinguished Professor of Medicine at UC San Diego and senior author of the paper. “All transcriptional biology is a balance of these co-activators and co-repressors.”
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