Crystallized Vitamin E
NIH-Funded Study Shows Increased Prostate Cancer Risk from Vitamin E Supplements
Men who took 400 international units (I.U.) of vitamin E daily had more prostate cancers compared to men who took a placebo, according to an updated review of data from the Selenium and Vitamin E Cancer Prevention (SELECT) Trial. The results of this update will appear October 12, 2011, in the Journal of the American Medical Association.
“SELECT has definitively shown a lack of benefit from vitamin E and selenium supplements in the prevention of prostate cancer and has shown there are some real risks,” said J. Kellogg Parsons, MD, MHS, one of the authors of the study and an investigator at UC San Diego Moores Cancer Center, which is part of the international network of research institutions (SWOG) that carried out SELECT at more than 400 clinical sites in the United States, Puerto Rico, and Canada. “Men who were part of SELECT should continue to see their primary care physician or urologist and bring these results to their attention for further consideration.”
The findings showed a 17 percent increase in prostate cancers relative to those who took a placebo. For every 1,000 men, there were 76 prostate cancers in men who took only vitamin E supplements, as compared to 65 in men on placebo, or 11 more cases of prostate cancer per 1,000 men.
Based on an independent safety monitoring review in September 2008, participants were told to stop taking their supplements because it had become clear that the trial would never produce the 25 percent reduction in prostate cancer the study was designed to show with the use of these supplements. In 2010, the study sites were closed and more than half of the participants consented to have their health monitored via mail questionnaires.